Beur schreef op 12 december 2017 17:31:
[...]Ja.
"If you have an HAE attack of the throat (laryngeal attack), inject FIRAZYR and then go to the nearest hospital emergency room right away."
www.firazyr.com/Ja.
"If you have an HAE attack of the throat (laryngeal attack), inject FIRAZYR and then go to the nearest hospital emergency room right away."
www.firazyr.com/-------------------------------------------
Voor de volledigheid:
Berinert® (CSL Behring) Human pasteurized, nanofiltered pdC1-INH
Europe: acute treatment & short-term prophylaxis
US: acute treatment only 20 U/kg, intravenous
Cinryze® (ViroPharma) Human pasteurized, nanofiltered pdC1-INH
Europe: acute treatment & prophylaxis
US: prophylaxis only 1000 U, intravenous
Ruconest® (Pharming) rhC1-INH Acute treatment (not for treatment of laryngeal attacks in the US) 50 U/kg,* intravenous (=84 kg: 4200 U)
Firazyr® (Shire) Icatibant, bradykinin 2 receptor antagonist Acute treatment 30 mg,† subcutaneous
Kalbitor® (Dyax) Ecallantide, kallikrein inhibitor Acute treatment (US only) 3 × 10 mg,‡ subcutaneous
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"Currently available clinical evidence suggests that pdC1-INH at a body weight-adjusted dose of 20 U/kg should be considered as the preferred treatment choice for treatment of acute laryngeal HAE attacks to ensure optimal treatment response."
pdC1-INH = C1INH op basis van plasma
www.sciencedirect.com/science/article...