Wall Street Trader schreef op 15 oktober 2020 15:09:
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GLPG1972, IPF’s assets and TOLEDO will be in the spotlight the upcoming 2/3 weeks.Starting with GLPG1972 which could become a first-in-class disease-modifying osteoarthritis drug and whose phase IIb topline data are expected in the end of this month. With no treatment available to counteract disease progression, OA represents an important unmet medical need.
These results are important for several reasons:
(1) with no competition in the market, if approved this asset could become Galapagos most significant value driver in the near future and
(2) this specific clinical trial could trigger Gilead decision to opt-in or not.
The opt-in fee for GLPG1972 is $250 million, with an additional $550 million in regulatory and commercial milestones if the option is exercised. Servier has rights to GLPG1972 outside the U.S.
Gilead, naturally, sees value as well. Linda Higgins and John Sundy, the respective heads of research external innovation and inflammation and respiratory diseases, note how it wasn't one particular asset that caught their company's attention, but rather Galapagos' chemistry, biology, and fast-paced drug development. "That drove a lot of the structure of the Gilead/Galapagos deal to preserve the things that are the real positives about Galapagos," Sundy said. "It was clear that independence was one of their aims, and one of ours was to expand our pipeline not just in size but in diversity," Higgins said.
Regarding the IPF’s portfolio topline results are anticipated of the ‘1205 PINTA phase2a, while ‘1690 ISABELA next update will be futility analysis in early 2021.
Finally, we get a significant update on the
“next level” TOLEDO program beginning with targets disclosure on the 27th of October.
TOLEDO has the potential to disrupt the inflammatory medicine market.The long-term upside potential in the future outweighs the downside risk at this entry point.
And also keep in mind money isn't everything, think of all the people with these chronic or pain diseases struggling everyday. Health is one of the crucial things in life money can't buy.www.glpg.com/docs/view/5f761fbab1628-en