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Draadje vogelgriep

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  1. [verwijderd] 20 januari 2006 12:30
    quote:

    flosz schreef:

    [quote=invoorentegenspoed]
    komt op mij over dat er tegenstrijdige berichten zijn m.b.t. werking Tamiflu...(of vergis ik me?)

    ivet
    [/quote]
    Klopt idd. Verschillende postings in dit draadje mbt Tamiflu/Relenza.

    Wijntje klinkt prettiger, en o.a. door de OPC blijf je er ook lekker "jong" (fris&fruitig) bij.
    Gr.(Pretpakket)

    Roche verdedigt natuurlijk hun produkt. Ik lees er geen tegenstrijdigheid in: het gaat om het tijdstip van toepassen van Tamiflu (als ik de berichten naast elkaar leg): de studie van Roche bevestigt dat toepasssen binnen 4 uur na infectie T. werkt. Gecontroleerde omstandigheden.

    Preventief gebruik van T. door bijv. vogelruimers zou effectief zijn. De effectiviteit vermindert sterk naarmate de tijd verstrijkt.
    Het probleem lijkt te zijn dat in de praktijk verschijnselen van griep pas na 1 of 2 dagen duidelijk worden na het moment van besmetting. Dan helpt T. niet meer.

  2. [verwijderd] 20 januari 2006 13:08
    quote:

    Gert50 schreef:

    [quote=Gert50]
    BF komt dichterbij: Griekenland.
    Bird flu is confirmed in Greece

    [/quote]

    Excuses: is oud bericht van oktober. Er zijn wel vandaag berichten op de Turkse radio i.v.m. vogelgriep in Griekenland, maar dat is nog niet bevestigd:

    Turkish channel, Haberturk had a "flash" report a few minutes ago saying BF was seen in many provinces of Greece and that there was a secret meeting last night with govnt officials and army staff about it.
    Geruchten houden aan:

    "Turkish Health Minister has announced that Greece has been hiding BF cases in several provinces in the last 2 months"

    wordt vervolgd.

  3. [verwijderd] 20 januari 2006 13:22
    Turkey says its neighbours covering up bird flu
    20 Jan 2006 10:11:31 GMT

    Source: Reuters

    ANKARA, Jan 20 (Reuters) - Turkey said on Friday its battle against a bird flu outbreak in people and poultry was being made harder by the failure of neighbouring countries to admit to having the deadly H5N1 virus.

    "It is unofficially known that this illness exists in our neighbouring countries which are ruled by closed regimes, but these countries do not declare this because of their systems," Agriculture Minister Mehdi Eker told a news conference.

    He did not name the countries but Iran and Syria are two likely targets of the criticism. Health experts are concerned neighbouring countries are not taking enough preventive measures against bird flu.

    Eker urged governors of Turkey's eastern provinces to be extra vigilant.

    Turkey has reported at least four deaths from the virus this month, bringing the H5N1 strain to the gates of Europe and the Middle East. The epicentre of Turkey's outbreak is in the east of the country bordering Syria, Iraq, Iran, and Armenia.

    Iran has said there had been no sign of the lethal H5N1 strain of bird flu on its territory.

    However, it has slaughtered tens of thousands of birds within 15 km (10 miles) of the Turkish border. It also banned the sale of Turkish fowl and closed the border to day trippers.

    Iraq has sent experts to the Kurdish region in the north of the country to search for signs of bird flu after the death of a teenage girl from a fever this week caused panic. The World Health Organisation has said she did not have the deadly virus.

    Syria has culled birds near the border with Turkey, but has said the birds had showed no sign of illness.

    Turkey has culled more than 1.1 million wild birds and poultry since the outbreak began two weeks ago, Eker said.

    Up to a third of the country is suspected of having bird flu among poultry and the Turks have reported 21 human cases, including the four deaths.

    Bird flu is known to have killed at least 80 people since late 2003. Victims contract the virus from close contact with infected birds, but there are fears it could mutate into a form that passes easily from person to person, sparking a pandemic in which millions could die.
    www.alertnet.org/thenews/newsdesk/L20...
  4. [verwijderd] 20 januari 2006 13:46
    Flosz,

    Mooie map ...
    De link staat niet helemaal goed in jouw posting. Het laatste deel neemt de hyperlink niet mee.

    Maar met copy and paste van volledige adres naar adresbalk lukt het wel.

    WB
  5. [verwijderd] 20 januari 2006 15:33

    PORTLAND, Ore. (Dow Jones)--AVI BioPharma Inc.'s (AVII) Neugene antisense technology was effective in preclinical experiments against several flu strains, according to findings of three independent laboratories.

    In a press release Friday, the drug developer said Neugene was tested against multiple flu strains including avian flu strain H5N1.

    AVI expects the confirmation data will lead to an Investigational New Drug application with the Food and Drug Administration.

    "These confirmations validate our approach to blocking replication of influenza viruses. We now believe that a single Neugene drug could be effective against most influenza subtypes, including the H5N1 avian strain," said AVI Senior Vice President Patrick L. Iversen in a statement.

    Company Web site: www.avibio.com

    -Eamon Beltran; Dow Jones Newswires; 201-938-5400; AskNewswires@dowjones.com


    (END) Dow Jones Newswires

  6. [verwijderd] 20 januari 2006 15:56
    quote:

    Dirk R. Wijnen schreef:

    AVII up, 18%.

    Crucell begint pas in april met klinische fasen.

    Dirk
    AVII up 27%.

    Volgens mij had Willem 1955 dit aandeel.

    Dirk
  7. [verwijderd] 20 januari 2006 16:02
    quote:

    Dirk R. Wijnen schreef:

    [quote=Dirk R. Wijnen]
    AVII up, 18%.

    Crucell begint pas in april met klinische fasen.

    Dirk
    [/quote]

    AVII up 27%.

    Volgens mij had Willem 1955 dit aandeel.

    Dirk
    Mooie stijging! Op hun website zie ik niks over Influenza. De pijplijn ziet er op het eerst gezicht niet slecht uit:

    www.avibio.com/devNeugene.html
  8. [verwijderd] 20 januari 2006 16:43
    quote:

    flosz schreef:

    Pandemic threat: interactive map

    Use this map to see which countries are most at threat from a pandemic such as avian flu, influenza or HIV/Aids.
    www.timesonline.co.uk/section/0,,26809,00.html



    Flosz,

    Op dezelfde site -"Share Ramping"-

    business.timesonline.co.uk/article/0,,9071-2002041,00.html

    Community service for Bhoyrul 'City Slicker'
    By Miles Costello and agencies



    Anil Bhoyrul, the former Daily Mirror journalist who pleaded guilty to his part in the "City Slickers" share-tipping scandal, has been handed a 180-community service order and walked away from a St Alban's crown court a free man today.



    Mr Bhoyrul, 38, made £15,000 from publishing share tips in the Slickers newspaper column, which he co-wrote with fellow financial journalist James Hipwell.

    The two journalists, who hooked up for the scam with day trader Terence Shepherd, employed the classic "buy, tip and sell" technique - described by the court today as a "cynical manipulation of the market".

    Mr Shepherd received a three-month prison sentence for his role in the scandal.

    The sentencing of Mr Hipwell, who has already been warned by the judge that he faced jail time, was adjourned due to his ill health. Sentencing will now await the results of medical tests.

    Mr Hipwell made nearly £41,000 from the scheme, which even threatened to implicate the Mirror's then-editor, Piers Morgan.

    Mr Morgan, who was accused by the court of lacking leadership, was fully cleared by an internal inquiry at the paper and an investigation by the Department of Trade & Industry.

    As he passed sentence in court today, Mr Justice Beatson said: "It falls to me to sentence you for conspiracy ... to create a misleading impression as to the value of investments by using the City Slickers column in the Daily Mirror to tip investments or otherwise publish information about them.

    "Bhoyrul, you were an associate editor of the Daily Mirror, responsible for the column, and with Hipwell wrote that column between you. Readers of the column did not know at the time it was being suggested by you that they should buy a share, because of what was said in the column, and that the tipsters were about to sell it."

    According to prosecutors, Hipwell and Bhoyrul - who now edits a magazine in Dubai - would buy shares at cheap prices, in the knowledge that they would soar in value once they were tipped in the newspapers financial pages.

    Having named the stocks as "tip of the day" in their column, they would then sell the shares for a profit as the price rose.

    Mr Shepherd, also convicted of being part of the share-ramping made a profit of £17,000.

    The scandal involved no fewer than 44 incidents between August 1 1999 and February 29 2000. Mr Hipwell and Mr Bhoyrul were both sacked from the Mirror in 2000.


  9. [verwijderd] 20 januari 2006 16:51
    Nog meer geruchten:

    Moldavia: 17 People Die of Bird Flu?

    13.01.2006 14:45

    Bird flue is raging in the Orkhei Region in Moldavia.

    The web edition of "The New Dniestrian Courier" reports that about 200 cases of people being infected with bird flu virus have been identified in Moldavia so far, most of them in the Orkhei Region. At least 17 people have already died.
    Officials in Kishinev have declined to comment on the report.

    inforos.com/?id=10444

    Het laatste zinnetje is niet geruststellend: “geen commentaar”. We gaan het zien.

  10. ejvdheuvel 20 januari 2006 17:24
    Hoi Dirk,

    Heb ze ook. Mooie rit geweest met AVII, tot nu toe. Minder dan een jaar geleden opgepikt voor 2.73 USD en nu op 190% winst. Het lijkt een beetje op CRXL, dat AVII, maar niet genoeg; superlong in CRXL!

    EJ
  11. [verwijderd] 20 januari 2006 17:25
    quote:

    ejvdheuvel schreef:

    Hoi Dirk,

    Heb ze ook. Mooie rit geweest met AVII, tot nu toe. Minder dan een jaar geleden opgepikt voor 2.73 USD en nu op 190% winst. Het lijkt een beetje op CRXL, dat AVII, maar niet genoeg; superlong in CRXL!

    EJ
    Hee EJ, harstikke goed voor je. Nu op 8.37, UP 42%

    't is je van harte gegund.

    Dirk
  12. [verwijderd] 20 januari 2006 20:31
    Bird Flu: Scientists Face Tough Challenges In Developing Vaccine

    By Julie A. Corwin



    Scientists in the United States are engaged in a practice run for a global bird-flu pandemic. They have created an experimental vaccine for the type of bird flu that currently exists. They are hoping that in the process of testing and developing this vaccine, they will learn how to produce an effective vaccine for a different, more dangerous form of the bird-flu virus -- one that could spread between humans.

    WASHINGTON, 20 January 2006 (RFE/RL) – Volunteers at the University of Maryland near Washington, D.C., participated in trials this month to test the effectiveness of a new experimental bird-flu vaccine. The vaccine was developed from a sample H5N1 strain of the virus taken from a Vietnamese patient in 2004.

    So far, the preliminary data from the test looks encouraging. That’s because the experimental vaccine did provoke an immune response in the volunteers -- the kind of response that can enable a body fight off an infection. But scientists do not know whether this experimental vaccine would be even partially effective against new virus strains were H5N1 to mutate.

    As scientists face the challenge of developing a vaccine against bird flu -- and particularly against a form of human-to-human transmitted bird flu that has yet to emerge -- they are discovering this particular disease presents its own surprises."The problem is that the strain of the disease that will allow human to human transmission -- which is really the serious problem that we're worried about -- doesn't exist yet," Maureen Lewis, a senior fellow at the Washington-based Center for Global Development, explains. "So we can't really develop a vaccine against that or an effective treatment because we don't know exactly what it looks like. And viruses are notoriously unstable."

    According to Lewis, scientists learned valuable lessons from an earlier global health scare, sudden acute respiratory syndrome (SARS). That flu-like illness started in China and eventually swept through 25 other countries from late 2002 to 2003.

    "The world community actually did a lot of research on SARS when it emerged," Lewis says. "And, you almost had a competition among the laboratories to figure out what the genome structure was so that they could develop a vaccine. And they did. And they did it very quickly. And in a sense, they are trying to do that now."

    But as scientists now face the challenge of developing a vaccine against bird flu -- and particularly against a form of human-to-human transmitted bird flu that has yet to emerge -- they are discovering this particular disease presents its own surprises.

    For example, they have found that even trying to protecting people against the current form of H5N1 carried by animals requires large amounts of the experimental vaccine.

    "The research that has been done so far has been very helpful in that it has shown us that when you make a vaccine the conventional way against H5N1 you have to use a lot more vaccine to get people to respond to it," says Dr. Andrew T. Pavia, chairman of the national public health committee of the Infectious Diseases Society of America and chief of pediatric infectious diseases at the University of Utah.

    "And, that was an important lesson, although a very disappointing and scary one," Pavia adds. "And, so now there is a great deal of research going on to try and make vaccines that are more efficient, so that you don't have to produce a lot more protein to put in somebody's arm in order to get a response. Hopefully, we will have those details worked out before we have to face an efficiently transmitted human-to-human H5N1."

    Any disease that requires large doses of vaccine for protection presents a problem because, everywhere in the world, the pharmaceutical sector’s capacity for producing vaccines is limited.

    "Currently the world capability is somewhere less than 500 million doses of vaccine with, you know, close to 6 billion people in the world," Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases in Washington, explains. "In addition, the dose that's required to induce an immune response with this particular vaccine is a significantly higher dose than the dose that you use to protect against the standard run-of-the-mill seasonal flu."

    Fauci says that U.S. government officials are concerned not only about inadequate manufacturing capacity but also about where that capacity is located. "We are tending much more towards making sure that we have pharmaceutical plants that are located on U.S. soil, so that we don't have a situation where if you have a global pandemic, then countries would obviously be nationalizing [their] factories," he says. "So, we want to work with other companies. We want to work with other countries. We want to work with international as well as domestic companies, but we don't want to have everything that we are doing be done outside of the United States, which is almost what is the situation right now."

    The Canadian government has already -- theoretically -- lined up enough vaccine supply for its citizens. It concluded a 10-year contract with a domestic supplier that is intended to ensure that there is enough bird-flu vaccine -- once an effective vaccine is found -- for every Canadian to receive a dose.

    However, countries such as Armenia, Ukraine, and Georgia have no domestic vaccine manufacturers, in part because vaccine production was concentrated in Russia during the Soviet era. But even Russia may have to depend on the largesse of the World Health Organization and other countries. Experts question whether Russian companies have the technical know-how, quality, and regulatory controls in place to produce a new vaccine quickly.
    www.rferl.org/featuresarticle/2006/01...
  13. [verwijderd] 20 januari 2006 21:46
    Meer details over de pre-klinische resultaten van Neugene ivm diverse influenza´s:

    The Business Journal of Portland - 11:54 AM PST Friday

    AVI BioPharma reports more success with Neugene

    AVI BioPharma Inc. on Friday announced confirmation from three independent laboratories of Neugene antisense efficacy in experiments against multiple strains of influenza, including avian influenza strain H5N1.
    As a result of the tests, AVI said said it plans to file with the Food and Drug Administration to begin human clinical trials of the drug for the treatment of strains of Influenza A, which includes the H5N1 virus.

    News of the test results pushed shares of AVI up as much as 50 percent in early trading Friday, setting a 52-week high at $8.88.

    Dr. P. Puthavathana at Mahidol University in Bangkok, Thailand, confirmed Neugene antisense efficacy against an H5N1 viral isolate in her assay system.

    Dr. Darwyn Kobasa at the Public Health Agency of Canada in Winnipeg, Manitoba, completed an initial dose-response study in cell culture demonstrating Neugene efficacy against both the H1N1 and H3N2 strains.

    Dr. Manoj Pastey at Oregon State University confirmed efficacy using the same Neugene antisense agents against the H7N7 and H3N8 strains.

    Taken together, the data confirms efficacy observed with the H1N1 strain previously reported from Drs. Jianzhu and Chen Qin Ge at Massachusetts Institute of Technology and now represent positive reports from four laboratories using different endpoints and methodologiesm, Portland-based (NASDAQ: AVII) AVI said.

    AVI is also conducting collaborative animal studies evaluating Neugene efficacy against influenza strains at Tulane University in New Orleans and at the U.S. Army Medical Research Institute of Infectious Disease in Frederick, Md.

    AVI's Neugene antisense drug development program against the influenza A virus specifically targets genetic regions of the virus that are highly conserved between six viral subtypes that cause human disease. These include three subtypes that caused pandemics in the 20th century -- the 1918 Spanish flu (H1N1), the 1957 Asian flu (H2N2) and the 1968 Hong Kong flu (H3N2) -- and three subtypes of avian flu that have been reported to cause disease in humans (H5N1, H7N7 and H9N2).




  14. [verwijderd] 20 januari 2006 22:00
    AVI Biopharma werkt met RNAI van SIRNA, Neugene is eerste toepassing? Is nog niet 100% bewezen?
    Als....... de resultaten straks in de trials goed zijn, lijkt het zeer veelbelovend.
  15. [verwijderd] 21 januari 2006 12:42
    Cheney says bird flu could pose economic risk

    20 Jan 2006 21:17:42 GMT

    Source: Reuters


    WASHINGTON, Jan 20 (Reuters) - Vice President Dick Cheney said on Friday that if avian flu were to arrive in the United States, it could deal a blow to the U.S. economy because of disruptions to businesses, schools and transportation systems.

    "It's the kind of thing I think that probably would have a major impact," Cheney told radio talk show host Hugh Hewitt. "There are things clearly that would have significant economic consequences were there to be such a pandemic."

    Cheney said in an interview early measures if there were signs of the disease included shutting down transportation systems and closing schools and public meeting places to minimize the possibility of transmission.

    H5N1 avian influenza now mostly affects birds but it has occasionally jumped to people, killing around 80 people in six countries. The fear is that the virus could mutate into a human influenza, spread quickly and kill millions globally.

    The virus has never been found in the United States, but the country is taking extensive precautions, including checking poultry and chicken products and taking part in international efforts to prevent a pandemic.

    On another topic, Cheney said the U.S. economy was performing "superbly" and said he was skeptical the boom in the U.S. housing market in recent years had developed into a bubble.

    "I'm not in a position today to be able to say there's a bubble out there. I'm not really confident that there is one," he said.

    The White House in recent weeks has launched an effort to publicize what it sees as upbeat data about the U.S. economy that it believes is not getting enough attention.

    Cheney said he believed positive economic news was not being "adequately covered in the press."

    "I think the mainstream press has more of a tendency to go to try to find problems and harp on those and spend a lot of time focused on those," he said.

    "But the bottom line is that a lot of people end up convinced that the economy is not doing very well, when, in fact, it's been performing superbly," Cheney said.
    www.alertnet.org/thenews/newsdesk/N20...
  16. [verwijderd] 21 januari 2006 12:44
    Bird flu confirmed in deaths of 2 Indonesian children

    21 Jan 2006 10:31:34 GMT

    Source: Reuters


    JAKARTA, Jan 21 (Reuters) - A Hong Kong laboratory has confirmed the H5N1 strain of bird flu killed two children from the same Indonesian family this month, a senior official at the Health Ministry said on Saturday.

    Indonesia has now had 14 confirmed deaths from bird flu, said the official, Hariadi Wibisono, director of control of animal-borne diseases at the ministry, and five cases where patients have survived.

    "These two cases have been confirmed positive from Hong Kong," Wibisono told Reuters by telephone, referring to the laboratory, which is recognised by the World Health Organisation (WHO).
    www.alertnet.org/thenews/newsdesk/JAK...
  17. [verwijderd] 21 januari 2006 12:48
    Turkey's Bird Flu Spread Shows Rich-Poor Divide, Risks EU Talks

    Jan. 20 (Bloomberg) -- Istanbul farmer Hasan Bozol owns a one- story house nestled among the city's high-rise blocks in the financial district, and his nine chickens live in the front yard.

    ``I'm not afraid of bird flu,'' said Bozol, 49, whose animals tend to wander into the street, forcing commuting bankers to screech their cars to a halt. ``Why should I kill my hens? I don't want to lose money.''

    An outbreak of Avian influenza this month has infected fowl and killed four people in the east of Turkey near the Iranian border, where incomes are just 30 percent of the Istanbul average. European Union officials are concerned the disease may spread further west unless the government eradicates poverty in a country where 40 percent of the people are farmers.

    Turkish authorities probably failed to see ``the scale of the problem early enough,'' EU Enlargement Commissioner Olli Rehn said in a Jan. 12 interview in Brussels.

    Turkey started talks to join the 25-nation bloc in October, and the financial divide is cited by the European Union as a hurdle. The country is counting on membership to get billions of dollars in investments and reduce unemployment of 9.7 percent.

    ``The outbreak showed the truth in what has now become a cliche: one side of Turkey is like Switzerland while the other is like Afghanistan,'' said Yarkin Cebeci, an economist at JPMorgan Chase & Co. in Istanbul, on Jan. 18.

    Thirteen Provinces

    Turkey on Dec. 28 reported an outbreak of avian influenza among fowl in an area bordering Iran. Four days later, four children were hospitalized in a neighboring province with suspected infection. The virus has since spread to 13 of 81 provinces and infected 21 people, killing four.

    Pictures published in European media that show village children running after fowl to help authorities in their culling efforts aren't helping Turkey's image, said Mehmet Gerz, head of research at Yapi Kredi Yatirim brokerage in Istanbul.

    ``These have strengthened the image of Turkey as being `very different' from Europe,'' Gerz said in an interview. ``These types of images lower public support for Turkey's bid further. The bird flu epidemic exposed once again the gap between eastern and western Turkey.''

    Worldwide, the H5N1 virus has killed at least 79 of the 148 people known to have been infected, the World Health Organization said Jan. 14. Apart from the Turkey cases, all were in eastern Asia, where the first bird-to-human transmission occurred in 2003.

    Response Delay

    The rising cases of the disease in birds increase the risk of the virus changing into a form more contagious to people. Health officials say such a development may start a pandemic similar to one that killed as many as 50 million people in 1918.

    Bird flu first appeared in Turkey in October in the western province of Balikesir. It was eradicated in days, winning authorities praise from the international community. The second outbreak in eastern Agri went undetected for a month, according to documents filed by Turkey at the Paris-based World Organization for Animal Health.

    The delay probably led to the spread of the virus, said Bernard Vallat, head of the Animal Health group.

    ``There are two different levels of administration in Turkey, this is clear,'' said Vallat in an interview in Beijing. ``The west is better administered with public veterinary services than in the east.''

    Child Deaths

    In Van in the east, Mehmet Emin Ozcan hesitated before taking his sick daughter to the hospital because of an unpaid debt to another state hospital from eight years ago, the father told Istanbul-based Hurriyet daily. Twelve-year-old Fatma Ozcan, who never went to school, died on Jan. 15.

    The Kocyigit family's four children played soccer with the head of a slaughtered sick chicken, according to neighbors' accounts in Istanbul-based daily Sabah. They hadn't heard of the avian influenza affecting people in Asia since 2003 or the virus's appearance in western Turkey two months earlier, which was reported in national media. Three of the four died.

    In Agri, the literacy rate is 68 percent, compared with the national average of 87 percent. In the Marmara region, Turkey's most developed western region which includes Istanbul, the rate is 92 percent, according to the State Planning Organization.

    Just 13 percent of children attend secondary school in Agri. Income per capita is $568 in Agri, compared with $3,268 in Marmara, government statistics show.

    Cull Compensation

    ``In remote villages of Turkey, it is possible that information on touching sick chicken being risky didn't reach people,'' said Bernardus Ganter, WHO regional adviser on communicable diseases, in Copenhagen on Jan. 5. ``In situations of poverty, people eat sick chicken.''

    The Turkish authorities must offer cash incentives to convince the rural poor to alter their way of life, according to the World Bank's office in Turkey.

    In a Jan. 17 speech, Prime Minister Recep Tayyip Erdogan said his government was paying ``every penny'' of compensation that farmers deserved. ``All our citizens should trust that the state is going to be there for them wherever the need rises.''

    Bozol isn't convinced.

    ``The government never pays what they say they will over sick animals or such,'' he said. ``If our fate is death, it will come from somewhere. If God wants that to be from birds, I can't argue against it.''
    www.bloomberg.com/apps/news?pid=10000...
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