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1. [verwijderd] 7 december 2005 14:08

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   DJ Vietnam Bans Sale Of Anti-Bird Flu Drug In Pharmacies
   
   12/07/2005
   Dow Jones News Services
   (Copyright © 2005 Dow Jones & Company, Inc.)
   
   
   HANOI (AP)--Vietnam has banned pharmacies from selling the anti-bird flu drug, Tamiflu, saying improper use could cause the virus to develop resistance to the medicine, officials said Wednesday.
   
   Residents afraid of contracting bird flu have rushed in recent weeks to buy the drug, which ranges from VND450,000 ($28) to VND1.2 million for one course of 10 capsules. All medicines are sold over-the-counter in Vietnam.
   
   But the Pharmaceutical Administration Department, under the Ministry of Health, has instructed provincial health departments and hospitals not to sell Tamiflu, said department director Cao Minh Quang.
   
   "Stockpiling and using the drug as a precautionary measure would be very dangerous, causing possible drug resistance," he said.
   
   Vietnam has already stockpiled 700,000 Tamiflu capsules, including 600,000 tablets donated by Taiwan, distributing a portion nationwide to hospitals designated to treat bird flu patients, he said. The goal is to acquire some 25 million Tamiflu tablets, he added.
   
   "The importation of the drug is very limited, we can't buy it," Quang said. "The No. 1 priority is for the national stockpile and for hospitals treating people infected with the H5N1 bird flu virus and suspected cases."
   
   Last month, Vietnam reached an agreement in principle with Tamiflu's manufacturer, Swiss-based Roche Holding AG (RHHBY), which would allow the communist country to make the drug with ingredients provided by Roche.
   
   The Ministry of Health is expected to recommend 10 Vietnamese pharmaceutical companies to Roche during a meeting this week, Quang said.
   
   Bird flu has killed or forced the slaughter of more than 100 million birds in Asia since the virus began ravaging farms in late 2003. It has also jumped to humans, killing at least 69 people in Asia, the majority of them in Vietnam.
   
   Experts fear the H5N1 virus could mutate into a form easily passed among people, potentially sparking a global pandemic. So far, most cases have been traced to contact with infected birds.
   
   Outbreaks have re-emerged in 20 provinces throughout Vietnam since October, killing or forcing the slaughter of more than 2 million birds.
   
   
   
2. [verwijderd] 8 december 2005 07:27

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   New China flu victim may mean bird cases undetected
   07 Dec 2005 10:21:00 GMT
   
   Source: Reuters
   
   
   BEIJING, Dec 7 (Reuters) - A Chinese village where a 10-year-old girl fell ill with bird flu had not reported any poultry outbreaks, indicating the virus might be going undetected or unreported, the World Health Organisation said on Wednesday.
   www.alertnet.org/thenews/newsdesk/PEK...
3. [verwijderd] 9 december 2005 10:01

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   Dutch to lift bird flu measures in January
   Thu Dec 8, 2005 8:42 AM ET
   
   AMSTERDAM (Reuters) - A ban in the Netherlands on keeping some poultry and other birds outdoors to prevent them from catching bird flu from migrating birds will be lifted on January 1, the farm ministry said on Thursday.
   
   "The peak period for bird migration is almost over and the monitoring of wild birds has not found any contamination," a ministry spokeswoman said.
   
   "The (agriculture) minister has decided to lift the measures but will make a final assessment of the situation at around mid-December," she added.
   
   
4. [verwijderd] 9 december 2005 10:13

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   Leuke zinsnede over 2,8 miljard voor een "cell-based flu vaccin"
   
   Avian flu outbreak would slam U.S. economy, report finds
   
   BY TONY PUGH
   
   Knight Ridder Newspapers
   
   WASHINGTON - A severe avian flu outbreak would cost the U.S. economy $625 billion - about 5 percent of the gross domestic product - as employers struggled with absenteeism, lost production and a sharp decline in consumer spending, a new government report has found
   
   The Bush administration has asked Congress for $7.1 billion to prepare for a flu pandemic. Part of it would go to increase the U.S. stockpile of antiviral drugs such as Tamiflu from 2.3 million full treatments to 81 million.
   
   President Bush also wants $1.2 billion to purchase 20 million full treatments of an experimental H5N1 vaccine
   >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
   and $2.8 billion for research into a cell-based flu vaccine
   >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
   that would allow American manufacturers to produce enough for the entire U.S. population within six months of a flu outbreak.
   
   www.mercurynews.com/mld/mercurynews/n...
   
   today.reuters.com/News/newsArticle.as...
   
   
5. [verwijderd] 9 december 2005 16:14

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   Pandemic Flu Spurs Race for New Vaccine Methods
   NPR - Thu Dec 8, 9:06 PM ET With governments and global health organizations taking the threat of a flu pandemic seriously, a big push is on to develop new and faster ways to make flu vaccines.
   
   news.yahoo.com/i/2142;_ylt=AsmOfNPwTS...
6. [verwijderd] 9 december 2005 18:52

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   Poor vaccines seen hampering bird flu efforts
   
   
   LONDON : Efforts to control the spread of bird flu in poultry in Southeast Asia are being hampered by the use of ineffective and often fake agricultural vaccines, a British virologist said Thursday.
   
   As a result, ineffective animal vaccines could be increasing the threat of the virus evolving and being able to pass to humans, triggering a potentially catastrophic pandemic, said animal flu specialist Robert Webster.
   
   To combat the problem, Webster, director of the World Health Organisation's Collaborating Centre for Studies on the Ecology of Influenza in Animals and Birds, called for more rigorous minimum standards for agricultural vaccines.
   
   "There are good vaccines and bad vaccines. Good vaccines reduce virus load; bad vaccines stop the signs of disease but the virus keeps replicating, spreading and evolving," he told reporters in London.
   
   "The chickens look perfectly healthy but go on pumping out viruses for a long time. We have to ask the question, why are these animal influenza viruses showing so much antigenic drift?
   
   "I would argue that contributing to this is the use of bad vaccines."
   
   Webster, who works in the United States, said ineffective vaccines were leading to apparently healthy birds spreading the virus and allowing it to evolve into new forms, each strain of which required separate vaccines.
   
   In Asia, the potentially deadly H5N1 strain has already split into as many as five different lineages, with different forms of the virus found in Vietnam and Indonesia, he explained.
   
   Millions of lives could be lost worldwide if one of the strains became able to be transmitted between humans or combined with one of the established, but less deadly, human flu virus strains, he argued.
   
   Currently, there are no requirements for animal flu vaccines to have minimum levels of antigens -- a protein from the target virus which switches on an immune response.
   
   By contrast, human flu vaccines must have 15 milligrammes of the circulating strains of the virus.
   
   Webster said scientists in China, which reported its fifth human case of bird flu Thursday, were producing some "excellent" high quality animal vaccines.
   
   But cheap, inferior ones were being made in small regional factories. In one instance, bottled water was reportedly sold as a vaccine, he said.
   
   "There should be international standards set," said Webster, who works at St Jude's Children's Research Hospital in Memphis, Tennessee.
   
   "Let's be scientific about this. We've already got five different lineages of H5N1 developing in Asia at the moment. We're generating more variants, and I think this is one of the major problems.
   
   "Let's put a standard amount of antigen into the vaccine. It's going to increase the cost a little bit but the advantage is enormous."
   
   Webster was speaking at a Medical Research Council (MRC) briefing in London, where world authorities on bird flu have gathered to discuss how to tackle the disease, which has claimed nearly 70 lives in Asia since late 2003.
   
   The body's ruling council is to be asked to a request for 10 million pounds (14.8 million euros, 17.5 million dollars) in extra funding for flu research over the next two years, MRC chief executive Colin Blakemore said. - AFP /dt
   
   www.channelnewsasia.com/stories/healt...
7. [verwijderd] 10 december 2005 16:17

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   We view cell culture as being a longer-term prospect that will take years before it is approved for actual manufacturing in the U.S.," said Matthews of Sanofi Pasteur. "It is a promising technology but one still in development. Until then, we must rely on egg-based manufacture. There is no quick fix for improving current influenza vaccine manufacturing methods."
   
   Sanofi Pasteur was awarded a $97 million contract from the U.S. Department of Health and Human Services to speed up the production process of cell-culture flu vaccines and the design of a manufacturing facility in the United States that could facilitate the production of 300 million flu vaccines annually. The majority of that contract is expected to be completed by 2008.
   
   www.foxnews.com/story/0,2933,178115,00.html
   
8. [verwijderd] 10 december 2005 21:35

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   Die man stopt gewoon het licht onder de korenmaat; ofwel maakt geen slapende honden wakker. Zullen we het eens op drie jaar houden??
9. Dachthetwelhe 10 december 2005 23:42

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   quote:

   oudje schreef:

   Die man stopt gewoon het licht onder de korenmaat; ofwel maakt geen slapende honden wakker. Zullen we het eens op drie jaar houden??
   

   Wederom een f-a-n-t-a-s-t-i-s-c-h-e bijdrage; bedankt opa. Ga liever een cursus engels volgen zou ik zeggen.
   Any questions ?
   
   Ik dacht even weer dat iedereen weer normaal tegen elkaar ging doen op dit forum; vergis ik mezelf even zeg.
10. [verwijderd] 12 december 2005 07:27

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    Associated Press
    Frist Warns Against Delaying Flu Funds
    12.11.2005, 11:55 AM
    
    Failure by Congress to immediately approve the president's request for $7.1 billion in emergency funds would hamper efforts to prepare for a possible outbreak of bird flu, Senate Majority Leader Bill Frist said Sunday.
    
    "It had better pass" before Congress adjourns for the year, said Frist, R-Tenn. "We need to be prepared. I'm very hopeful that we will invest $7.1 billion to look at prevention, to look at care, to look at treatment."
    
    Federal officials spent four hours on Saturday in a drill to see how well the government was ready to handle an outbreak. They said saving lives will require more planning in local communities and increased vaccine production.
    
    The prospects for the $7.1 billion are not clear. Conservatives in the House oppose rubber-stamping the request without finding spending cuts elsewhere in the budget.
    www.forbes.com/technology/feeds/ap/20...
11. [verwijderd] 12 december 2005 07:48

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    Hi Flosz
    Excuse me, heb dit abusievelijk ook in RT geplaatst....
    Je was me weer voor...
12. [verwijderd] 13 december 2005 07:57

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    Roche provides worldwide Tamiflu supply update
    
    By Wai Lang Chu
    12/12/2005 - Roche has responded to recent criticism that it was protecting its avian-flu formula too closely by identifying 12 prospective partners to increase the global production of Tamiflu.
    
    Worldwide demand for the vaccine has increased ten fold after concerns over growing cases of avian flu and the possibility of a flu pandemic. This has led to more people than usual seeking vaccination against seasonal flu, even though this would not protect against a pandemic strain.
    Roche, one of a number of vaccine manufacturers contracted to supply various governments with flu vaccines, has identified a list of 12 potential partners from an original shortlist of around 200 third parties interested in Roche's Global Tamiflu Supply Network.
    
    Roche also revealed that it planned to grant a sub-license for China to Shanghai Pharmaceutical Group. The sub-licensing for the production of oseltamivir for pandemic use in China becomes the first one for the country, a move that extends Roche's vaccine presence in the Asian market.
    
    In light of the Avian Flu outbreak in South East Asia, Roche's presence has not been more essential. Roche said that in countries such as Vietnam, Roche would provide capsules or active pharmaceutical ingredient for third parties to encapsulate locally.
    
    The pharmaceutical company also identified India where it would be delivering 100,000 treatment courses of Tamiflu ordered by the Indian Government and where negotiations about a local sub-license are ongoing with local manufacturers.
    
    In Thailand, Philippines and Indonesia, Tamiflu is not patent protected and these governments are free to purchase or manufacture oseltamivir at their discretion.
    
    "As yet we have not identified anyone who could significantly speed up the agreed delivery timelines for the first half of 2006, but we have been able to identify partners to insure against breakdowns in supply and partners to broaden geographic coverage," commented William Burns, CEO Roche Pharma Division.
    
    "Based on the current orders we have received from governments around the world our capacity to produce 300 million treatments by 2007 are significantly ahead of demand."
    
    Roche has also pledged to donate 3 million treatments to the WHO as a rapid response stockpile for use at the epicentre of a pandemic. According to experts, this could contain or slow down the spread of a potential pandemic at the source of the outbreak, if delivered rapidly.
    
    "The supply chain now being put in place exceeds our current orders from World Governments. During 2006 our supply chain will grow dramatically reaching an annualised 300 million plus treatments by the start of 2007," said David Reddy, Roche Pandemic Task Force Leader.
    
    "We are now also in the position to have a back-up supply in case of an emergency and specific geographic coverage has also been enhanced with suppliers in Europe, the Americas and Asia," he added.
    www.in-pharmatechnologist.com/news/ng...
13. [verwijderd] 14 december 2005 08:21

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    U.S. FDA warns makers of 'bogus' flu remedies
    Tue Dec 13, 2005 3:54 PM ET
    
    
    By Maggie Fox, Health and Science Correspondent
    WASHINGTON (Reuters) - The U.S. Food and Drug Administration said on Tuesday it had warned nine companies to stop marketing "bogus" flu products.
    
    The products, including capsules that allegedly contain bacteria from dirt and other assorted immune system "boosters," all claim or claimed to help prevent or treat avian flu.
    
    "FDA is not aware of any scientific evidence that demonstrates the safety or effectiveness of these products for treating or preventing avian flu and the agency is concerned that the use of these products could harm consumers or interfere with conventional treatments," the agency said in a statement.
    
    "The use of unproven flu cures and treatments increases the risk of catching and spreading the flu rather than lessening it because people assume they are protected and safe and they aren't," said Dr. Andrew von Eschenbach, acting FDA commissioner.
    
    "I consider it a public health hazard when people are lured into using bogus treatments based on deceptive or fraudulent medical claims."
    
    All of the companies sell via Internet Web sites and the FDA complained about several claims, including "prevents avian flu," "a natural virus shield," "kills the virus," and "treats the avian flu."
    
    Most are promoted as being "natural" or "safer" treatments that can be used in place of approved drugs.
    
    "In the Warning Letters, FDA advises the firms that it considers their products to be drugs because they claim to treat or prevent disease," the FDA said.
    
    today.reuters.com/news/newsArticle.as...
14. [verwijderd] 15 december 2005 09:23

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    Earlier this year GSK predicted that the global vaccine market could quadruple in size by 2015 to £17-£24 billion from its current level of around £5 billion (€7.4 billion).
    
    This anticipated growth has sparked a number of mergers and acquisitions within the industry of late, with Crucell recently announcing a merger with Berna Biotech and Novatris intending to buy the remaining 58 per cent of Chiron it does not already own in an attempt to get in on the vaccine action.
    www.in-pharmatechnologist.com/news/ng...
15. [verwijderd] 15 december 2005 11:06

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    At the end of 2007, potentially we could cover between 20 and 25 percent of the European population ... If (a pandemic) happens next week, there will be a shortage (of vaccines) but if it happens in 2007, there will probably be enough," he added.
    
    Over coming months, the European Commission will look into creating a "European strategic stock" of vaccines to supplement the national supplies and attempt to shorten vaccine production times.
    
    news.yahoo.com/s/afp/20051214/hl_afp/
    healthflueusweden_051214171739;_ylt=Ajvt18ViVD5BYfaBZZNRt6Ws0NUE;_ylu=X3oDMTA3czJjNGZoBHNlYwM3NTE-
    
16. [verwijderd] 16 december 2005 14:08

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    Pandemic would shock economy In worst-case scenario, flu outbreak could trigger global recession, experts say
    
    By MARK HUME
    
    Friday, December 16, 2005 Page S3
    
    VANCOUVER -- When an influenza pandemic next strikes the world, as it is predicted to do sooner or later, its most important impact will be on the health of individuals.
    
    But participants in a pioneering conference in British Columbia yesterday heard about a second front where a disease outbreak will register shock waves: on the health of businesses and the global economy.
    
    Some financial projections predict a pandemic will trigger a global recession, with the worldwide trade of goods and services contracting by about 14 per cent, the equivalent of $2.5-trillion.
    
    While the focus of most governments has been on medical aspects of a pandemic, experts attending the Pacific Pandemic Forum for Business said corporate planning can be almost as important.
    
    "Planning is critical. . . . Business continuity and contingency planning is what this is all about," said Andrew Wilkinson, deputy minister for the B.C. Ministry of Economic Development.
    
    He said it was the first conference of its kind in North America.
    
    Erik Bloom, an economist with the Asian Development Bank, said it is difficult to predict what will happen economically, given all the unknowns about the next pandemic.
    
    But he presented some scenarios, saying that while the numbers aren't firm, they do paint a broad picture of what might happen.
    
    He said two scenarios were developed, both assuming a relatively mild pandemic that kills three million Asians, but with different levels of psychological impact on the population. In the most severe case, the world would be forced into a recession, and the estimated loss in Asia would be about $282-billion, around 6.5 percentage points of the gross domestic product for East, South and Southeast Asia.
    
    He said it would take Asia's economy three years to recover -- but he stressed that Asia and the world would bounce back economically, comparing it to the recession of the late 1980s.
    
    "We took our lumps and recovered then," he said. "It would certainly not be a major depression."
    
    Angela Trudeau, senior researcher with BMO Financial Group, said all businesses in Canada would be affected, even those that wouldn't have employees off sick.
    
    "It's all of our problem," she said, stressing that supply chains are far more interlinked than at any time in history.
    
    "Look at your purchase orders. . . . If you were to analyze how many companies in how many countries you deal with, you'd be surprised," she said. "You could say we are handcuffed together."
    
    Ms. Trudeau said it is not cynical for business leaders to plan ways to minimize the impact of a pandemic, because by staying in operation they contribute not just to their own corporate well-being, but to the stability of society.
    
    "We've also got to take care of business -- and if you do that you'll be contributing significantly," she said.
    
    Ms. Trudeau told the 100 people in attendance that just by discussing and preparing for a pandemic they are taking a big step, because their advance knowledge will help lower the level of panic that will occur when a disease outbreak strikes.
    
    Danuta Skowronski, an epidemiologist with the BC Centre for Disease Control, said an influenza pandemic is inevitable, although nobody can predict when it will happen.
    
    "The clock is ticking, but we don't know what time it is," she said, outlining how the H5N1 avian-flu virus has spread to 16 countries in Asia and, more recently, to Europe.
    
    The B.C. Ministry of Health has established a website to help individuals and organizations plan for a pandemic. It is located at: www.healthservices.gov.bc.ca/pho/pand...
    www.theglobeandmail.com/servlet/Artic...
17. [verwijderd] 16 december 2005 16:36

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    CSL hopes for bird-flu vaccine application by Aug
    16 Dec 2005 05:00:51 GMT
    
    Source: Reuters
    
    MELBOURNE, Dec 16 (Reuters) - Australia's CSL Ltd. <CSL.AX> hopes to apply for local regulatory approval for a prototype vaccine against the H5N1 bird flu by August 2006 at the earliest.
    
    CSL, the world's largest maker of human plasma products, expects results on its trials on healthy adults of two different doses of its flu vaccine by February.
    
    If results prove its vaccine is effective and the Therapeutic Goods Administration agrees on the dose for a candidate vaccine, CSL would do further trials on infants and the elderly before submitting a vaccine application, CSL's chief scientific officer, Andrew Cuthbertson, said on Friday.
    
    "And then we would file for registration of a prototype pandemic vaccine in the third quarter of 2006," he told reporters.
    
    A CSL spokeswoman said the company would be ready to submit an application in August at the earliest and that it was unclear how long the approval process would take, but it was likely to be much faster than normal.
    
    Cuthbertson said the company would be looking at data from Sanofi Pasteur's <SASY.PA> early-stage trials of a vaccine, which the French company said on Thursday had been encouraging.
    
    Sanofi Pasteur found that 30 micrograms of viral antigen with an adjuvant -- an additive that boosts the immune response -- given in two doses showed an immune response consistent with the requirements of regulators to approve seasonal influenza vaccine.
    
    It also found immune responses in volunteers who had been given lower doses.
    
    CSL is focusing on lower doses, testing 7.5 micrograms and 15 micrograms, looking to come up with the smallest dose that is effective, given the world's limited manufacturing capacity for flu vaccines.
    
    "In a crisis situation, this dose question becomes absolutely critical," Cuthbertson said.
    
    The Australian government committed this week to spend A$16.6 million on buying pandemic influenza antivirals as soon as a vaccine was found to be safe and effective.
    www.alertnet.org/thenews/newsdesk/SYD...
18. [verwijderd] 16 december 2005 17:41

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    The report also warned that local health services could collapse under the strain and recommended that the government accelerate vaccine production and possibly even encourage manufacturers to invest in new technology.
    *************************************
    
    Boost preparations for bird flu -report
    Fri Dec 16, 2005 12:07 AM GMT
    
    
    LONDON (Reuters) - Britain must improve its contingency planning for a possible bird flu outbreak and give greater support to global efforts to prevent a pandemic, a parliamentary committee said on Friday.
    
    Experts say a flu pandemic among humans could kill millions around the globe and cause major economic losses. The deadly H5N1 virus is endemic in poultry in parts of Asia where it has killed 71 people since late 2003.
    
    The committee said Britain should contribute more to improve surveillance of avian flu in Asia and ensure a rapid response to an outbreak of a new virus strain to prevent it spreading.
    
    It also said Britain should urgently look at how antiviral drugs can best be used, revise its purchasing policy and provide more detailed guidance for health workers.
    
    "A flu pandemic looks likelier now than at any time since the 1960s," said Lord Broers, chairman of the House of Lords Science and Technology Committee, which has no power to force the government to act.
    
    "But it's not inevitable and with co-ordinated international action it can still be prevented. The government must put its weight behind U.N. agencies working in south east Asia."
    
    He said Britain had a head start on many countries in contingency planning.
    
    "But the government could still do better, both by issuing fuller guidance to frontline health workers and by protecting essential services such as food distribution networks," he said.
    
    He suggested the creation of a cabinet-level post with responsibility for contingency planning.
    
    The report also warned that local health services could collapse under the strain and recommended that the government accelerate vaccine production and possibly even encourage manufacturers to invest in new technology.
    
    Britain should also provide cash, staff and technical expertise to boost its "half-hearted" backing of international efforts to fight a possible pandemic, said Broers.
    
    
19. [verwijderd] 16 december 2005 17:51

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    16/12/2005 : Bank Degroof : Crucell BUY , target : 26 Euro .
    
20. [verwijderd] 16 december 2005 20:07

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    Van Lanschot zit ook op € 26. Hebben ze meer dingen gemeen??